Journal
FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2013.00180
Keywords
cytokine; interleukin-1; inflammation; decoy receptor
Categories
Funding
- European Commission (European Research Council) [MUGEN LSHG-CT-2005-005203, MUVAPRED LSH-CT-2003-503240, TIMER HEALTH F4-2011-281608]
- Ministero dell'Istruzione, dell'Universita e della Ricerca [progetto FIRB RBLA039LSF]
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Fondazione CARIPLO
- Italian Cystic Fibrosis Research Foundation
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Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of ILI R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and receptors with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
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