Journal
FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2013.00006
Keywords
graft-vs-host disease; autoimmunfty; cancer; graft tolerance; immunoregulation; double negative T cells
Categories
Funding
- Diabete Quebec scholarship
- Canadian Institutes of Health Research
- Leukemia/Lymphoma Society of Canada
- Canadian Institutes of Health Research New Investigator scholarship
- Foundation of the Maisonneuve-Rosemont Hospital
- National Sciences and Engineering Research Council of Canada
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A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity. Interestingly, CD4(-) CD8(-) (double negative, DN) T cells, which exhibit a unique antigenspecific immunoregulatory potential, appear to exhibit all of the properties to respond to these challenges. Herein, we review the therapeutic potential of immunoregulatory DN T cells in various immunopathological settings, including graft tolerance, GVHD, cancer, and autoimmunity.
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