Journal
FRONTIERS IN IMMUNOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2013.00265
Keywords
next generation sequencing; antibody; repertoire; antibodyome; humoral immune response; synthetic library; deep sequencing
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In the decade since the human genome sequence was declared complete, the development of next generation sequencing (NGS) or deep sequencing to deliver cost-effective genomic sequencing has influenced advances beyond its primary application and changed the research landscape in many other areas. This review will survey recent applications of NGS which have broadened the understanding of natural antibody repertoires (the antibodyome) and how these evolve in response to viral infection. We will also report examples where deep sequencing of binding populations, derived from both natural and synthetic repertoires, have been used to benefit antibody engineering.This knowledge will ultimately lead to the design of more effective biological drugs and vaccines.
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