Journal
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
Volume 23, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s12199-018-0732-1
Keywords
SDQ; Bisphenol A; Phthalates; Prenatal exposure; Birth cohort; Behavioral problems
Categories
Funding
- Ministry of Health, Labour and Welfare of Japan, JSPS KAKENHI [JP16H02645, JP16K16619]
- nvironment Research and Technology Development Fund from Ministry of the Environment, Japan [5-1454]
Ask authors/readers for more resources
Background: Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. Methods: The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels in the first trimester maternal serum was determined by LC-MS/MS for 458 children. Variables used for adjustment were parental ages, maternal cotinine levels, family income during pregnancy, child sex, birth order, and age at SDQ completed. Results: The median concentrations of BPA, MnBP, MiBP, MEHP, and MECPP, primary and secondary metabolites of phthalates, were 0.062, 26.0, 7.0, 1.40, and 0.20 ng/ml, respectively. MECPP level was associated with increase conduct problem risk (OR = 2.78, 95% CI 1.36-5.68) overall and the association remained after child sex stratification, and odds ratios were increased with wider confidence interval (OR = 2.85, 95% CI 1.07-7.57 for boys, OR = 4.04, 95% CI 1.31-12.5 for girls, respectively). BPA, Sigma DBPm (MnBP + MiBP), and Sigma DEHPm (MEHP+MECPP) levels were not associated with any of the child behavioral problems. Conclusions: Our analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available