Journal
CURRENT OSTEOPOROSIS REPORTS
Volume 10, Issue 3, Pages 190-198Publisher
SPRINGER
DOI: 10.1007/s11914-012-0109-0
Keywords
Signaling; Pathways; Osteoblasts; Osteoclasts; Osteocytes; Parathyroid hormone; Wnt; Growth factors; MAPKs; PI3K; Calciumsensing receptor; Osteoporosis; Sclerostin; Dkk1; Integrins; Cadherins; Connexins; Ephrins; Skeletal health
Categories
Ask authors/readers for more resources
Skeletal health is dependent on the balance between bone resorption and formation during bone remodeling. Multiple signaling pathways play essential roles in the maintenance of skeletal integrity by positively or negatively regulating bone cells. During the last years, significant advances have been made in our understanding of the essential signaling pathways that regulate bone cell commitment, differentiation and survival. New signaling anabolic pathways triggered by parathyroid hormone, local growth factors, Wnt signaling, and calcium sensing receptor have been identified. Novel signals induced by interactions between bone cells-matrix (integrins), osteoblasts/osteocytes (cadherins, connexins), and osteoblasts/osteoclast (ephrins, Wnt-RhoA, semaphorins) have been discovered. Recent studies revealed the key pathways (MAPK, PI3K/Akt) that critically control bone cells and skeletal mass. This review summarizes the most recent knowledge on the major signaling pathways that control bone cells, and their potential impact on the development of therapeutic strategies to improve human bone health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available