Journal
CURRENT OPINION IN INSECT SCIENCE
Volume 30, Issue -, Pages 86-92Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cois.2018.09.009
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Funding
- JSPS KAKENHI [17H01472]
- MAFF Genomics-Based Technology for Agricultural Improvement [PRM-3002]
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Neonicotinoids are insecticides that target insect nicotinic acetylcholine receptors (nAChRs), exhibiting high selective toxicity to insects over vertebrates and good systemic activity in crop plants. For these reasons, neonicotinoids currently make up similar to 30% of insecticide sales worldwide. However, due to their adverse impact on pollinators such as honey bees and bumble bees, neonicotinoids are being banned from the EU, and other countries may follow. It is therefore crucial to understand the mechanism underlying neonicotinoid actions on pollinators as well as on the nAChRs of pests, with a view to understanding their selectivity. Here we review the molecular mechanisms of neonicotinoid actions at an atomic level, through structural and resistance mechanism studies and propose relevant research topics for further studies on the future of pest management.
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