Journal
CURRENT OPINION IN INSECT SCIENCE
Volume 1, Issue -, Pages 73-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cois.2014.05.002
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Funding
- NIH (NINDS) [R00NS062953, R01NS077933]
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Though expressed in relatively few neurons in insect nervous systems, pigment-dispersing factor (PDF) plays many roles in the control of behavior and physiology. PDF's role in circadian timekeeping is its best-understood function and the focus of this review. Here we recount the isolation and characterization of insect PDFs, review the evidence that PDF acts as a circadian clock output factor, and discuss emerging models of how PDF functions within circadian clock neuron network of Drosophila, the species in which this peptide's circadian roles are best understood.
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