Journal
CURRENT OPINION IN CHEMICAL ENGINEERING
Volume 3, Issue -, Pages 42-50Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coche.2013.11.001
Keywords
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Funding
- National Institutes of Health [U54CA143868]
- National Science Foundation [1054415]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1054415] Funding Source: National Science Foundation
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Vascularization of tissue-engineered constructs, requiring the transport of oxygen, nutrients and waste through a thick and cellular dense meshwork, continues to hamper the success of the technology in addressing the donor organ shortage crisis. Microfluidic technology has emerged as a viable alternative to traditional in vitro platforms utilized by tissue engineers, to understand how the complex cellular microenvironment directs vascular cell behavior and functionality. In this review, the essence of microfluidic technology and transport phenomenon that make them unique for vascular tissue engineering will be briefly introduced. The main scope of this review is to expose how new and innovative microfluidic fabrication techniques are being utilized for exciting applications that have allowed insight into the spatio/temporal dynamics of vascular cell behavior. Specifically, microfluidic devices which range in functionality from simultaneously controlling oxygen and shear stress levels to perfusable biopolymer networks, will be discussed in the context of how they bolster traditional in vitro platforms, by providing greater data output, accessibility, and physiological relevance.
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