Pharmaceutical nanocrystals

Development of poorly soluble and/or permeable drug molecules using nanocrystal formulations has proven to be highly successful due to the greater surface/volume ratio, resulting in improvements in dissolution and bioavailability as well as enhanced permeability. These submicron 'nanoparticles' have similar benefits to conventional nanoparticles which are less than 100 nm but are scalable and can be applied in all existing manufacturing processes and dosage forms. This opinion focuses on recent developments in the preparation of nanocrystals and the role of surface properties on optimizing dissolution and targeted delivery. Some key technical challenges and environmental impact are also considered.