Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents

The influence of three types of halogen-substituted E-beta-methyl-beta-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing beta-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the beta-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the beta-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds.