Journal
APPLIED SCIENCES-BASEL
Volume 4, Issue 2, Pages 171-179Publisher
MDPI
DOI: 10.3390/app4020171
Keywords
Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction
Categories
Funding
- National Science Foundation [CHE-0548150]
- URC at the University of Cincinnati
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1058627] Funding Source: National Science Foundation
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Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction.
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