4.7 Article

Cleavage of the C-C triple bond of ketoalkynes: synthesis of 4(3H)-quinazolinones

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 2, Issue 4, Pages 366-368

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4qo00260a

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Funding

  1. Program for Minjiang Scholar program [10BS216]
  2. Xiamen Southern Oceanographic Center [13GYY003NF16]
  3. NSF of China [21202048]
  4. Promotion Program for Young and Middle-aged Teachers in Science and Technology Research of Huaqiao University [ZQN-PY120]

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A novel protocol for the synthesis of 4(3H)-quinazolinones via selective cleavage of the triple bond of ketoalkynes under oxidant-, metal-, and ligand-free conditions has been developed. Various 4(3H)-quinazolinones were obtained through fragmentation of the C-C triple bond and formation of two C-N bonds.

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