Journal
ANNUAL REVIEW OF VIROLOGY, VOL 1
Volume 1, Issue -, Pages 427-451Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-031413-085355
Keywords
viral vector; DNA transfer; parvovirus; gene therapy; transduction
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Adeno-associated virus (AAV) is a small, nonenveloped virus that was adapted 30 years ago for use as a gene transfer vehicle. It is capable of transducing a wide range of species and tissues in vivo with no evidence of toxicity, and it generates relatively mild innate and adaptive immune responses. We review the basic biology of AAV, the history of progress in AAV vector technology, and some of the clinical and research applications where AAV has shown success.
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