Journal
ONCOIMMUNOLOGY
Volume 4, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/2162402X.2014.994398
Keywords
cAMP; immunosenescence; regulatory T cells; toll-like receptor; tumor immunotherapy; tumor microenvironment
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Funding
- NCI NIH HHS [R01 CA184379] Funding Source: Medline
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Understanding molecular mechanisms involved in creating and sustaining the tumor suppressive microenvironment is critical for the development of novel antitumor therapeutic strategies. We have identified the induction of T cell senescence as a novel mechanism utilized by human tumor cells to induce immune suppression, and provided a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy.
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