Journal
ONCOIMMUNOLOGY
Volume 4, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/2162402X.2014.984547
Keywords
cancer; IL-17; survival; tumor microenvironment; Th17
Categories
Funding
- Dutch Cancer Society [UL2010-4801]
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Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17(+) cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17(+) cells.
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