Journal
ONCOIMMUNOLOGY
Volume 4, Issue 8, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1021538
Keywords
gamma delta T cell; cancer; DC-mediated gamma delta T cell activation; dendritic cell; immunotherapy
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Funding
- Research Foundation Flanders (FWO) [FWO G.0399.14N]
- Belgian Foundation against Cancer [2012-193]
- Belgian public utility foundation VOCATIO
- University of Antwerp
- Belgian Hercules Foundation
- Institute for the Promotion of Innovation through Science and Technology (IWT) (Belgium)
- Flemish League against Cancer
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Gamma delta (gamma delta) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunostimulatory cytokines and ability to promote the generation of tumor antigen-specific CD8(+) and CD4(+) T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the gamma delta T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated gamma delta T cell activation and related opportunities for tumor immunologists.
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