Journal
ONCOIMMUNOLOGY
Volume 5, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1093278
Keywords
BM mesenchymal stromal cells; BM microenvironment; bone disease; disease prognosis; IL-13; IL-17; IL-22; multiple myeloma; Th17 cells; Th22 cells
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Funding
- Italian Association for Cancer Research (AIRC) [IG-11353, IG-11340]
- Fondazione Umberto Veronesi
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We recently reported that in multiple myeloma increased Th22 cell frequencies correlate with poor prognosis. Here we show that within the same patients' cohort Th17 cells associate with bone disease and not with prognosis. Thus, we propose that Th22 and Th17 cells play non-redundant roles in multiple myeloma and constitute independent therapeutic targets.
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