Journal
ONCOIMMUNOLOGY
Volume 5, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1095434
Keywords
Cancer immunotherapy; NKG2D ligands; nonblocking sMIC-neutralizing anti-MIC antibody; soluble MIC
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Human tumor-derived soluble NKG2D sMIC paralyzes the immune system through multiple pathways. Targeting soluble MIC with a nonblocking sMIC-neutralizing anti-MIC antibody effectuated and revamped endogenous innate and adoptive antitumor responses. Therapy induced regression of primary tumors and eliminated metastasis in preclinical models.
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