4.6 Editorial Material

A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4+ T-cell maturation

Journal

ONCOIMMUNOLOGY
Volume 4, Issue 9, Pages -

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1026536

Keywords

CD4(+) T cells; colitis-associated colorectal cancer; thymus; tumor suppression; TSSP

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The maturation of a specific subset of CD4(+) T lymphocytes in the thymus is dependent on cortical thymic epithelial cells expressing the protease thymus-specific serine protease (TSSP, also known as PRSS16). Recently, we unveiled the involvement of TSSP in tumor suppression through its effect on the CD4(+) T compartment.

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