Journal
ONCOIMMUNOLOGY
Volume 4, Issue 9, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1016708
Keywords
NK cell tolerance; KIR; HLA; ADCC; rituximab; obinutuzumab; lirilumab; CD20
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Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance.
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