Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1052934
Keywords
Anti-tumor immunity; adenosine receptors; CD8+T cells; immunotherapies; oxygen; natural killer cells; tumor microenvironment; vaccine
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Funding
- NCI NIH HHS [R01 CA111985] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA111985] Funding Source: NIH RePORTER
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Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
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