Journal
ONCOIMMUNOLOGY
Volume 8, Issue 10, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1072672
Keywords
Tasquinimod; suppressive myeloid cells (SMCs); immunotherapy; myeloid-derived suppressor cells (MDSCs); tumor associated macrophages (TAMs)
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Infiltrating myeloid derived suppressor cells and tumor-associated macrophages (TAMs) are important components of the immunosuppressive tumor microenvironment. We recently reported that tasquinimod, which binds to S100A9, impairs both infiltration and function of these cells. Here we discuss the underlying mechanisms responsible for targeting multiple suppressive populations and the modulation of the tumor microenvironment.
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