Journal
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
Volume 6, Issue 1, Pages 53-68Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1756283X12454590
Keywords
Clostridium difficile; inflammatory bowel disease; microbial dysbiosis
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Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological conditions like Clostridium difficile infection or inflammatory bowel disease (IBD). In this review, we focus on the role of microbial dysbiosis in initiation of C. difficile infection and IBD, and we also touch upon the role of specific pathogens, particularly C. difficile, as causative agents of IBD. We also discuss the molecular mechanisms activated by C. difficile that contribute to the development and exacerbation of gastrointestinal disorders.
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