Journal
STEM CELL REPORTS
Volume 2, Issue 5, Pages 662-674Publisher
CELL PRESS
DOI: 10.1016/j.stemcr.2014.03.011
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Funding
- Research Center Network for Realization of Regenerative Medicine, MEXT
- Grants-in-Aid for Scientific Research [24592688] Funding Source: KAKEN
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In this article, we show that mouse embryonic stem cell-or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a proof of concept'' for retinal sheet transplantation therapy for advanced retinal degenerative diseases.
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