Journal
ONCOIMMUNOLOGY
Volume 4, Issue 6, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/2162402X.2014.974399
Keywords
cancer immunotherapy; immune checkpoints; PD-1; macrophages; MDSCs
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Infiltration by immunosuppressive myeloid cells helps tumors to overcome immune surveillance and can render patients less responsive to therapeutic intervention. Several recent studies have demonstrated that reprogramming myeloid responses can effectively enhance cancer immunotherapy, suggesting several new potential combination therapies for clinical testing.
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