Journal
ONCOIMMUNOLOGY
Volume 5, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1005522
Keywords
cytokines; melanoma; myeloid cells; NF-kappa B; T cells; tumor-associated macrophages
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Funding
- NATIONAL CANCER INSTITUTE [R01CA034590, R01CA116021] Funding Source: NIH RePORTER
- Veterans Affairs [I01BX002301] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA034590, R01 CA116021] Funding Source: Medline
- BLRD VA [IK6 BX005225, I01 BX002301] Funding Source: Medline
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Recent breakthroughs in therapeutic modulation of immune cells have led to novel exciting treatments for cancers. Moreover, the cytokine milieu in the tumor microenvironment is important for appropriate immune surveillance. Here, we demonstrate that NF-kappa B activity in myeloid cells is essential for cytokine-mediated antitumor polarization of immune cells.
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