Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1052929
Keywords
BRAF inhibitor; macrophage; melanoma; targeted therapy
Categories
Funding
- NATIONAL CANCER INSTITUTE [P30CA010815] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA010815] Funding Source: Medline
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We have recently discovered that BRAF inhibitors induce potent macrophage responses that confer melanoma resistance to therapy. Our studies lay a foundation for the hypothesis that macrophages switch their role from a passenger to a driver for tumor survival during therapeutic treatment, suggesting that agents that target macrophages can be an important component of cocktail anticancer therapy.
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