Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1050574
Keywords
CD8+; human colorectal cancer; myeloperoxidase; prognostic markers; tissue microarray
Categories
Funding
- SNF [PP00P3-133699, 31003A-122235, 320030-120320]
- Italian Association for Cancer Research (AIRC) [10555]
- Lazio Regional Agency for Transplantation and Related Diseases
- Dr. Hans Altschueler Stiftung
- Swiss National Science Foundation (SNF) [31003A-122235, 320030-120320] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Colorectal cancer (CRC) infiltration by cells expressing myeloperoxidase (MPO) or CD8 positive T lymphocytes has been shown to be independently associated with favorable prognosis. We explored the relationship occurring between CD8+ and MPOC cell CRC infiltration, its impact on clinical-pathological features and its prognostic significance in a tissue microarray (TMA) including 1,162 CRC. We observed that CRC showing high MPO+ cell infiltration are characterized by a prognosis as favorable as that of cancers with high CD8+ T cell infiltration. However, MPO+ and CD8+ CRC infiltrating cells did not synergize in determining a more favorable outcome, as compared with cancers showing MPOhigh/CD8(low) or MPOlow/CD8(high) infiltrates. Most importantly, we identified a subgroup of CRC with MPOlow/CD8(low) tumor infiltration characterized by a particularly severe prognosis. Intriguingly, although MPO+ and CD8+ cells did not co-localize in CRC infiltrates, an increased expression of TIA-1 and granzyme-B was detectable in T cells infiltrating CRC with high MPOC cell density.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available