Journal
ONCOIMMUNOLOGY
Volume 4, Issue 12, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1054599
Keywords
CTL; immune checkpoint blockade; invasive margin; Plexin; semaphorin; tumor rejection; tumor associated macrophage; tumor stroma
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Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.
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