Journal
NATURE PLANTS
Volume 1, Issue 2, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NPLANTS.2014.24
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Funding
- NSF [IOS-1147265, NSF-1027446]
- New Scholar Award from Ellison Medical Foundation
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1147265] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1027445] Funding Source: National Science Foundation
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Pre-mitotic establishment of polarity is a key event in the preparation of mother cells for asymmetric cell divisions that produce daughters of distinct fates, and ensures correct cellular patterning of tissues and eventual organ function. Previous work has shown that two receptor-like kinases, PANGLOSS2 (PAN2) and PAN1, and the small GTPase RHO GTPASE OF PLANTS (ROP) promote mother cell polarity and subsequent division asymmetry in developing maize stomata. PAN proteins become polarized prior to asymmetric cell division, however, the mechanism of this polarization is unknown. Here we show that the SCAR/WAVE regulatory complex, which activates the actin-nucleating ARP2/3 complex, is the first known marker of polarity in this asymmetric division model and is required for PAN polarization. These findings implicate actin, and specifically branched actin networks, in PAN polarization and asymmetric cell division.
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