Journal
NEUROIMAGE-CLINICAL
Volume 6, Issue -, Pages 445-454Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2014.10.009
Keywords
FDG-PET imaging; Statistical Parametrical Mapping; Voxel-based analysis; Dementia diagnosis
Categories
Funding
- European Union's Seventh Framework Programme (FP7) [HEALTH-F2-2011-278850]
- 7th Framework Programme for Research and Technological Development DECIDE [RI-261593]
- Fondazione Eli-Lilly (Eli-Lilly grant Imaging of neuroinflammation and neurodegeneration in prodromal and presymptomatic Alzheimer's disease phases
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Diagnostic accuracy in FDG-PET imaging highly depends on the operating procedures. In this clinical study on dementia, we compared the diagnostic accuracy at a single-subject level of a) Clinical Scenarios, b) Standard FDG Images and c) Statistical Parametrical (SPM) Maps generated via a new optimized SPM procedure. We evaluated the added value of FDG-PET, either Standard FDG Images or SPM Maps, to Clinical Scenarios. In 88 patients with neurodegenerative diseases (Alzheimer's Disease-AD, Frontotemporal Lobar Degeneration-FTLD, Dementia with Lewy bodies-DLB and Mild Cognitive Impairment-MCI), 9 neuroimaging experts made a forced diagnostic decision on the basis of the evaluation of the three types of information. There was also the possibility of a decision of normality on the FDG-PET images. The clinical diagnosis confirmed at a long-term follow-up was used as the gold standard. SPM Maps showed higher sensitivity and specificity (96% and 84%), and better diagnostic positive (6.8) and negative (0.05) likelihood ratios compared to Clinical Scenarios and Standard FDG Images. SPM Maps increased diagnostic accuracy for differential diagnosis (AD vs. FTD; beta 1.414, p = 0.019). The AUC of the ROC curve was 0.67 for SPM Maps, 0.57 for Clinical Scenarios and 0.50 for Standard FDG Images. In the MCI group, SPM Maps showed the highest predictive prognostic value (mean LOC = 2.46), by identifying either normal brain metabolism (exclusionary role) or hypometabolic patterns typical of different neurodegenerative conditions. (C) 2014 Published by Elsevier Inc.
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