Journal
NEUROIMAGE-CLINICAL
Volume 2, Issue -, Pages 558-568Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2013.03.016
Keywords
Bipolar disorder; White matter; Neuroimaging; DTI; Brain mapping; Fractional anisotropy
Categories
Funding
- National Institute of Mental Health [K24 MH001848, R21 MH075944, R01 MH084955, 5F31MH078556]
- National Institute for Biological Imaging and Bioengineering [R01 EB008432, R01 EB007813, P41 RR013642]
- National Center for Research Resources [RR12169, RR13642, RR00865]
- Brain Mapping Medical Research Organization
- Brain Mapping Support Foundation
- Pierson-Lovelace Foundation
- Ahmanson Foundation
- William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation
- Tamkin Foundation
- Jennifer Jones-Simon Foundation
- Capital Group Companies Charitable Foundation
- Robson Family
- Northstar Fund
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Background: Bipolar disorder (BD) is a chronic mental illness characterized by severe disruptions in mood and cognition. Diffusion tensor imaging (DTI) studies suggest that white matter (WM) tract abnormalities may contribute to the clinical hallmarks of the disorder. Using DTI and whole brain voxel-based analysis, we mapped the profile of WM anomalies in BD. All patients in our sample were euthymic and lithium free when scanned. Methods: Diffusion-weighted and T1-weighted structural brain images were acquired from 23 lithium-free euthymic subjects with bipolar I disorder and 19 age-and sex-matched healthy control subjects on a 1.5 T MRI scanner. Scans were processed to provide measures of fractional anisotropy (FA) and mean and radial diffusivity (MD and RD) at each WM voxel, and processed scans were nonlinearly aligned to a customized brain imaging template for statistical group comparisons. Results: Relative to controls, the bipolar group showed widespread regions of lower FA, including the corpus callosum, cortical and thalamic association fibers. MD and RD were abnormally elevated in patients in many of these same regions. Conclusions: Our findings agree with prior reports of WM abnormalities in the corpus callosum and further link a bipolar diagnosis with structural abnormalities of the tapetum, fornix and stria terminalis. Future studies assessing the diagnostic specificity and prognostic implications of these abnormalities would be of interest. (C) 2013 The Authors. Published by Elsevier Inc. Open access under CC BY-NC-SA license.
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