Journal
NANOTECHNOLOGY REVIEWS
Volume 1, Issue 6, Pages 493-513Publisher
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/ntrev-2012-0033
Keywords
controlled release; drug delivery; light responsive; magnetic nanoparticles; nanomaterials
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The controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. Coupled with excellent biocompatibility profiles, various nanomaterials have showed great promise for biomedical applications. Stimuli-responsive nanomaterials guarantee the controlled release of cargo to a given location, at a specific time, and with an accurate amount. In this review, we have combined the major stimuli that are currently used to achieve the ultimate goal of controlled and targeted release by smart nanomaterials. The most heavily explored strategies include (1) pH, (2) enzymes, (3) redox, (4) magnetic, and (5) light-triggered release.
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