Journal
NANOMATERIALS
Volume 3, Issue 2, Pages 221-228Publisher
MDPI AG
DOI: 10.3390/nano3020221
Keywords
graphene; DNA; adsorption; fluorescence; separation; gel electrophoresis
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Funding
- University of Waterloo
- Canada Foundation for Innovation
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Ontario Ministry of Research and Innovation
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Separation of short single- and double-stranded DNA typically requires gel electrophoresis followed by DNA extraction, which is a time consuming process. Graphene oxide adsorbs single-stranded DNA more quickly than double-stranded ones, allowing for selective removal of the former with a simple mixing and centrifugation operation. The effect of DNA length and salt on adsorption selectivity has been characterized and its application in DNA melting curve measurement has been demonstrated.
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