Journal
MOLECULAR METABOLISM
Volume 4, Issue 10, Pages 665-677Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molmet.2015.07.005
Keywords
Adipose tissue; Macrophage; Apoptosis; Cleaved caspase-3; NF-kappa B; Survival
Categories
Funding
- NHLBI NIH HHS [T32 HL007411] Funding Source: Medline
- NIDDK NIH HHS [P30 DK058404, F31 DK100144] Funding Source: Medline
- NIGMS NIH HHS [R25 GM062459] Funding Source: Medline
- BLRD VA [I01 BX002195] Funding Source: Medline
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Objective: Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survival during obesity has yet to be explored. Results: We demonstrate that activation of apoptotic pathways is significantly reduced in ATMs from diet-induced and genetically obese mice. Concurrently, pro-survival Bcl-2 family member protein levels and localization to the mitochondria is elevated in ATMs from obese mice. This increased pro-survival signaling was associated with elevated activation of the transcription factor, NF-kappa B, and increased expression of its pro-survival target genes. Finally, an obesogenic milieu increased ATM viability only when NF-kappa B signaling pathways were functional. Conclusions: Our data demonstrate that obesity promotes survival of inflammatory ATMs, possibly through an NF-kappa B-regulated mechanism. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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