Journal
MULTIPLE SCLEROSIS AND RELATED DISORDERS
Volume 26, Issue -, Pages 37-39Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2018.08.029
Keywords
TNF alpha blockers; Demyelinating lesions; NMOSD; MOG-IgG
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Tumor necrosis factor alpha (TNF alpha) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical autoimmune events including demyelinating lesions of the central nervous system (CNS). We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNF alpha therapy for a pustular psoriasis.
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