Journal
LANCET DIABETES & ENDOCRINOLOGY
Volume 2, Issue 10, Pages 810-818Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S2213-8587(14)70146-9
Keywords
-
Categories
Funding
- EU [LSHM_CT_2006_037197]
- Medical Research Council Epidemiology Unit [MC_UU_12015/1, MC_UU_12015/5]
- Medical Research Council Human Nutrition Research [MC_UD99999906]
- Cambridge Lipidomics Biomarker Research Initiative [G0800783]
- Cancer Research UK
- Health Research Fund of the Spanish Ministry of Health
- Murcia Regional Government [6236]
- Regional Government of Navarre
- Dutch Ministry of Public Health, Welfare and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON
- World Cancer Research Fund
- Statistics Netherlands
- Swedish Research Council
- Novo Nordisk
- Swedish Diabetes Association
- Swedish Heart-Lung Foundation
- German Cancer Aid
- German Ministry of Research
- Medical Research Council UK
- Danish Cancer Society
- Asturias Regional Government
- Vasterboten County Council
- AIRE-ONLUS Ragusa
- AVIS-Ragusa
- Sicilian Regional Government
- Imperial College Biomedical Research Centre
- NL Agency [IGE05012]
- MRC [MC_UP_A100_1003, MC_UP_A090_1006, MC_UU_12015/1, MC_UU_12015/5] Funding Source: UKRI
- Cancer Research UK [16491] Funding Source: researchfish
- Medical Research Council [MC_UU_12015/5, MC_UU_12015/1, MC_UP_A090_1006, G0401527, MC_UP_A100_1003, MC_U106179471, G1000143] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0512-10135] Funding Source: researchfish
Ask authors/readers for more resources
Background Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants. Methods The EPIC-InterAct case-cohort study includes 12 403 people with incident type 2 diabetes and a representative subcohort of 16 154 individuals who were selected from a cohort of 340 234 European participants with 3 . 99 million person-years of follow-up (the EPIC study). Incident type 2 diabetes was ascertained until Dec 31, 2007, by a review of several sources of evidence. Gas chromatography was used to measure the distribution of fatty acids in plasma phospholipids (mol%); samples from people with type 2 diabetes and subcohort participants were processed in a random order by centre, and laboratory staff were masked to participant characteristics. We estimated country-specific hazard ratios (HRs) for associations per SD of each SFA with incident type 2 diabetes using Prentice-weighted Cox regression, which is weighted for case-cohort sampling, and pooled our findings using random-effects meta-analysis. Findings SFAs accounted for 46% of total plasma phospholipid fatty acids. In adjusted analyses, different individual SFAs were associated with incident type 2 diabetes in opposing directions. Even-chain SFAs that were measured (14: 0 [myristic acid], 16: 0 [palmitic acid], and 18: 0 [stearic acid]) were positively associated with incident type 2 diabetes (HR [95% CI] per SD difference: myristic acid 1.15 [95% CI 1.09-1.22], palmitic acid 1.26 [1.15-1.37], and stearic acid 1.06 [1.00-1.13]). By contrast, measured odd-chain SFAs (15: 0 [pentadecanoic acid] and 17: 0 [heptadecanoic acid]) were inversely associated with incident type 2 diabetes (HR [95% CI] per 1 SD difference: 0.79 [0.73-0.85] for pentadecanoic acid and 0.67 [0.63-0.71] for heptadecanoic acid), as were measured longer-chain SFAs (20: 0 [arachidic acid], 22:0 [behenic acid], 23:0 [tricosanoic acid], and 24:0 [lignoceric acid]), with HRs ranging from 0.72 to 0.81 (95% CIs ranging between 0.61 and 0.92). Our findings were robust to a range of sensitivity analyses. Interpretation Different individual plasma phospholipid SFAs were associated with incident type 2 diabetes in opposite directions, which suggests that SFAs are not homogeneous in their effects. Our findings emphasise the importance of the recognition of subtypes of these fatty acids. An improved understanding of differences in sources of individual SFAs from dietary intake versus endogenous metabolism is needed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available