Journal
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
Volume -, Issue 59, Pages -Publisher
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/3570
Keywords
Bioengineering; Issue 59; thermal ablation; surface plasmon resonance; nanoparticle; nanotechnology; silver seeds
Categories
Funding
- National Science Foundation Partnerships for Research and Education in Materials (PREM) [DMR-0934218]
- National Center For Research Resources [2G12RR013646-11]
- NATIONAL CENTER FOR RESEARCH RESOURCES [G12RR013646] Funding Source: NIH RePORTER
- National Institute on Minority Health and Health Disparities [G12MD007591] Funding Source: NIH RePORTER
- Division Of Human Resource Development [0932339] Funding Source: National Science Foundation
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The physical, chemical and optical properties of nano-scale colloids depend on their material composition, size and shape (1-5). There is a great interest in using nano-colloids for photo-thermal ablation, drug delivery and many other biomedical applications (6). Gold is particularly used because of its low toxicity (7-9). A property of metal nano-colloids is that they can have a strong surface plasmon resonance (10). The peak of the surface plasmon resonance mode depends on the structure and composition of the metal nano-colloids. Since the surface plasmon resonance mode is stimulated with light there is a need to have the peak absorbance in the near infrared where biological tissue transmissivity is maximal (11), (12). We present a method to synthesize star shaped colloidal gold, also known as star shaped nanoparticles (13-15) or nanostars (16). This method is based on a solution containing silver seeds that are used as the nucleating agent for anisotropic growth of gold colloids (17-22). Scanning electron microscopy (SEM) analysis of the resulting gold colloid showed that 70 % of the nanostructures were nanostars. The other 30 % of the particles were amorphous clusters of decahedra and rhomboids. The absorbance peak of the nanostars was detected to be in the near infrared (840 nm). Thus, our method produces gold nanostars suitable for biomedical applications, particularly for photo-thermal ablation.
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