Journal
JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
Volume 43, Issue 1, Pages 3-11Publisher
KOREAN ACAD PERIODONTOLOGY
DOI: 10.5051/jpis.2013.43.1.3
Keywords
Epithelial cells; Host-pathogen interactions; Immune evasion; Neutrophils; Perodontitis
Categories
Funding
- National Research Foundation of Korea through the Oromaxillofacial Dysfunction Research Center for the Elderly [2011-0024650]
- Korean Government
- National Research Foundation of Korea [2008-0062281, 2011-0024650] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interaction of nonperiodontopathic versus periodontopathic bacteria with innate immune components encountered in the gingival sulcus will be described. In particular, we will describe the susceptibility of these microbes to antimicrobial peptides (AMPs) and phagocytosis by neutrophils, the induction of tissue-destructive mediators from neutrophils, the induction of AMPs and interleukin (IL)-8 from gingival epithelial cells, and the pattern recognition receptors that mediate the regulation of AMPs and IL-8 in gingival epithelial cells. This review indicates that true periodontal pathogens are poor activators/suppressors of a host immune response, and they evade host defense mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available