The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma

The pathogenesis of multiple myeloma ( MM) remains unclear and the NLRP3 inflammasome has been more and more recognized in the progression of many diseases. To investigate the role of the NLRP3 inflammasome in MM, we determined the genetic polymorphisms and expression of NLRP3 inflammasome-related genes IL-1 beta, IL-18, CARD8, and NF-kappa B) in MM patients, and explored their clinical relevance. Furthermore, we investigated the relationship of the NLRP3 inflammasome with Th cells in MM. Our study showed that the CARD8-C10X rs2043211) AT genotype contributed to the susceptibility of MM. CARD8C10X TT patients had earlier clinical stage. The WBC count in the three CARD8 genotypes showed an increasing trend AA