The Role of the gamma delta T Cell in Allergic Diseases

The predominant distribution of gamma delta T cells in the mucosal and epithelial tissues makes these unconventional lymphocytes the guards to contact external environment (like allergens) and to contribute to immune surveillance, as well as vanguards to participate in initiating mucosal inflammation. Therefore, gamma delta T cells have been considered to bridge the innate and adaptive immunity. The role these cells play in allergy seems to be complicated and meaningful, so it makes sense to review the characteristics and role of gamma delta T cells in allergic diseases.