Journal
JOURNAL OF BIOLOGICAL DYNAMICS
Volume 8, Issue 1, Pages 117-134Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17513758.2014.913718
Keywords
predator-prey interactions; ecological stoichiometry; tumour growth; cancer modelling; 92B05; 93D20; 92C50
Categories
Funding
- University Grants Commission, New Delhi [37-483/2009(SR)]
Ask authors/readers for more resources
In this paper, we consider a continuous mathematically tractable model and its discrete analogue for the tumour growth. The model formulation is based on stoichiometric principles considering tumour-immune cell interactions in potassium (K (+))-limited environment. Our both continuous and discrete models illustrate cancer immunoediting' as a dynamic process having all three phases namely elimination, equilibrium and escape. The stoichiometric principles introduced into the model allow us to study its dynamics with the variation in the total potassium in the surrounding of the tumour region. It is found that an increase in the total potassium may help the patient fight the disease for a longer period of time. This result seems to be in line with the protective role of the potassium against the risk of pancreatic cancer as has been reported by Bravi et al. [Dietary intake of selected micronutrients and risk of pancreatic cancer: An Italian case-control study, Ann. Oncol. 22 (2011), pp. 202-206].
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available