Journal
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Volume 9, Issue -, Pages 139-150Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/COPD.S38938
Keywords
chronic obstructive pulmonary disease; chronic bronchitis; mucus; sputum
Categories
Funding
- NHLBI NIH HHS [K23 HL094696] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K23HL094696] Funding Source: NIH RePORTER
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Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination of mucus are the primary mechanisms responsible for excessive mucus in chronic bronchitis. Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality. Nonpharmacologic options for the treatment of mucus accumulation in COPD are smoking cessation and physical measures used to promote mucus clearance. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics.
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