Journal
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Volume 7, Issue -, Pages 523-535Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/COPD.S28247
Keywords
skeletal muscle; pulmonary rehabilitation; exercise; quadriceps; diaphragm
Categories
Funding
- National Institute for Health Research (NIHR) Respiratory Biomedical Research Unit, Royal Brompton and Harefield Foundation Trust and Imperial College
- NIHR postdoctoral fellowship
- Biomedical Research Unit
- NIHR Clinician Scientist Award
- Medical Research Council New Investigator Award
- Medical Research Council [G1002113] Funding Source: researchfish
- National Institute for Health Research [PDF-2011-04-048, DHCS/07/07/009] Funding Source: researchfish
- MRC [G1002113] Funding Source: UKRI
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The skeletal muscles play an essential role in life, providing the mechanical basis for respiration and movement. Skeletal muscle dysfunction is prevalent in all stages of chronic obstructive pulmonary disease (COPD), and significantly influences symptoms, functional capacity, health related quality of life, health resource usage and even mortality. Furthermore, in contrast to the lungs, the skeletal muscles are potentially remedial with existing therapy, namely exercise-training. This review summarizes clinical and laboratory observations of the respiratory and peripheral skeletal muscles (in particular the diaphragm and quadriceps), and current understanding of the underlying etiological processes. As further progress is made in the elucidation of the molecular mechanisms of skeletal muscle dysfunction, new pharmacological therapies are likely to emerge to treat this important extra-pulmonary manifestation of COPD.
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