Journal
JOURNAL OF TRAUMA NURSING
Volume 22, Issue 2, Pages 111-116Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JTN.0000000000000115
Keywords
0.9% saline; Acid-base disturbance; Hyperchloremia; Lactated ringers; Normal saline; Plasmalyte
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In the acute care setting, the type and amount of fluid administered has a significant impact on patient outcomes. In particular, 0.9% saline infusions are known to cause or exacerbate hyperchloremia. The studies presented evaluate possible complications from 0.9% saline infusions. These studies compared administration of 0.9% saline with lactated ringer or plasmalyte in the acute care setting. In each trial, the patients who were randomized to receive 0.9% saline infusions had a more severe acidosis from increased serum chloride levels. From the available data, chloride-restrictive intravenous fluid such as plasmalyte appears to reduce acid-base disturbances and improve patient outcomes.
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