Related references
Note: Only part of the references are listed.Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms
Thomas Michler et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial
Rene Westhovens et al.
ANNALS OF THE RHEUMATIC DISEASES (2013)
Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-Activated Protein Kinase-2 Inhibits Endothelial Inflammation via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase Activity
Kyung-Sun Heo et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover
Tobias Braun et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
Pharmacokinetics, Safety, and Tolerability of GLPG0259, a Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5) Inhibitor, Given as Single and Multiple Doses to Healthy Male Subjects
Florence Namour et al.
Drugs in research & development (2013)
Interleukin-1β Assembles a Proangiogenic Signaling Module Consisting of Caveolin-1, Tumor Necrosis Factor Receptor-Associated Factor 6, p38-Mitogen-Activated Protein Kinase (MAPK), and MAPK-Activated Protein Kinase 2 in Endothelial Cells
Joanna Jagielska et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)
Characterization of the cellular action of the MSK inhibitor SB-747651A
Shaista Naqvi et al.
BIOCHEMICAL JOURNAL (2012)
Analogs of the RSK inhibitor SL0101: Optimization of in vitro biological stability
Michael K. Hilinski et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors
Xianhai Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis
Martin J. I. Andrews et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The macrophage response towards LPS and its control through the p38MAPK-STAT3 axis
Johannes G. Bode et al.
CELLULAR SIGNALLING (2012)
MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1
Samira Ziaei et al.
EXPERIMENTAL CELL RESEARCH (2012)
Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner
Shuko Terazawa et al.
EXPERIMENTAL DERMATOLOGY (2012)
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
John J. O'Shea et al.
IMMUNITY (2012)
NF-κB and the link between inflammation and cancer
Joseph A. DiDonato et al.
IMMUNOLOGICAL REVIEWS (2012)
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo(1,5-a)pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach
Tomomi Kosugi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
PRAK Suppresses Oncogenic ras-Induced Hematopoietic Cancer Development by Antagonizing the JNK Pathway
Naoto Yoshizuka et al.
MOLECULAR CANCER RESEARCH (2012)
MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE
John M. Kyriakis et al.
PHYSIOLOGICAL REVIEWS (2012)
Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo
Akihito Muto et al.
VASCULAR PHARMACOLOGY (2012)
Signaling in Innate Immunity and Inflammation
Kim Newton et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU-Rich Element-Dependent Translation
Christopher Tiedje et al.
PLOS GENETICS (2012)
Arsenic Exposure, Dietary Patterns, and Skin Lesion Risk in Bangladesh: A Prospective Study
Brandon L. Pierce et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2011)
Angiotensin II modulates interleukin-1β-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-κB crosstalk
Shanqin Xu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Juergen Scheller et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
Allard Kaptein et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model
Simon Chang et al.
CANCER INVESTIGATION (2011)
Unfolded Protein Response Signaling and MAP Kinase Pathways Underlie Pathogenesis of Arsenic-Induced Cutaneous Inflammation
Changzhao Li et al.
CANCER PREVENTION RESEARCH (2011)
The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor
Sergiy Kostenko et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
Depletion of 14-3-3 Protein Exacerbates Cardiac Oxidative Stress, Inflammation and Remodeling Process via Modulation of MAPK/NF-kappa B Signaling Pathways after Streptozotocin-induced Diabetes Mellitus
Rajarajan A. Thandavarayan et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)
IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES
P. Seidel et al.
EUROPEAN RESPIRATORY JOURNAL (2011)
The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice
Trine Bertelsen et al.
EXPERIMENTAL DERMATOLOGY (2011)
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Angiotensin II-Induced Inflammation and Hypertension Regulation of Oxidative Stress
Talin Ebrahimian et al.
HYPERTENSION (2011)
Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3 MK2 MEDIATES LIPOPOLYSACCHARIDE-INDUCED SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION 3 (STAT3) ACTIVATION BY PREVENTING NEGATIVE REGULATORY EFFECTS OF MK3
Christian Ehlting et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Cell-penetrating peptides can confer biological function: Regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides
Jamie L. Brugnano et al.
JOURNAL OF CONTROLLED RELEASE (2011)
The role of p38 mitogen-activated protein kinase in the pathogenesis of inflammatory bowel disease
Ya Jing Feng et al.
JOURNAL OF DIGESTIVE DISEASES (2011)
Tristetraprolin Regulates Interleukin-6 Expression Through p38 MAPK-Dependent Affinity Changes with mRNA 3′ Untranslated Region
Wenpu Zhao et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2011)
Silencing Mitogen-Activated Protein Kinase-Activated Protein Kinase-2 Arrests Inflammatory Bone Loss
Qiyan Li et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment
Sandra L. Clement et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Marie Cargnello et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)
Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes
N. Ronkina et al.
NUCLEIC ACIDS RESEARCH (2011)
The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly
Azlinda Anwar et al.
PLOS ONE (2011)
MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages
Joanne Darragh et al.
BIOCHEMICAL JOURNAL (2010)
MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
Natalia Ronkina et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
Juraj Velcicky et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I
Laszlo Revesz et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: Menage a trois or menage a quatre?
Alexey Shiryaev et al.
CELLULAR SIGNALLING (2010)
Induction of insulin-like growth factor-I by interleukin-17F in bronchial epithelial cells
M. Kawaguchi et al.
CLINICAL AND EXPERIMENTAL ALLERGY (2010)
Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRK-beta
Wei Wang et al.
ELECTROPHORESIS (2010)
Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation
Hongying Wang et al.
FASEB JOURNAL (2010)
The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages
Justin P. Edwards et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2010)
The role of Toll-like receptors in chronic inflammation
Stefan K. Drexler et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
TLRs and chronic inflammation
Caroline Ospelt et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Tumor Necrosis Factor Receptor-associated Factor-6 and Ribosomal S6 Kinase Intracellular Pathways Link the Angiotensin II AT1 Receptor to the Phosphorylation and Activation of the IκB Kinase Complex in Vascular Smooth Muscle Cells
Priscilla Doyon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment
Francesco P. Marchese et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hunting for Serine 276-Phosphorylated p65
Anneleen Spooren et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
Simone Radtke et al.
JOURNAL OF CELL SCIENCE (2010)
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation
Arndt J. Schottelius et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)
MK2 Signaling: Lessons on Tissue Specificity in Modulation of Inflammation
Nanna Fyhrquist et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury
Nader Ghasemlou et al.
JOURNAL OF NEUROSCIENCE (2010)
A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor α Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation
Robert J. Mourey et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
PHOSPHORYLATION STATUS OF HEAT SHOCK PROTEIN 27 REGULATES THE INTERLEUKIN-1β-INDUCED INTERLEUKIN-6 SYNTHESIS IN C6 GLIOMA CELLS
K. Tanabe et al.
NEUROSCIENCE (2010)
Synthesis of SL0101 Carbasugar Analogues: Carbasugars via Pd-Catalyzed Cyclitolization and Post-Cyclitolization Transformations
Mingde Shan et al.
ORGANIC LETTERS (2010)
Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis
Yong-Yu Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)
IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway
Mio Kawaguchi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)
Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor
Luciana B. Lopes et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
MK2 regulates the early stages of skin tumor promotion
Claus Johansen et al.
CARCINOGENESIS (2009)
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
Sergiy Kostenko et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Targeting protein kinases for the development of anti-inflammatory drugs
Philip Cohen
CURRENT OPINION IN CELL BIOLOGY (2009)
Eicosanoids in inflammation and cancer: the role of COX-2
Smita Agarwal et al.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2009)
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages
Corina Tudor et al.
FEBS LETTERS (2009)
Molecules in focus: Cytosolic phospholipase A2-α
Marzieh Niknami et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Tristetraprolin Mediates Interferon-γ mRNA Decay
Rachel L. Ogilvie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Reduced Oxazolone-Induced Skin Inflammation in MAPKAP Kinase 2 Knockout Mice
Anne T. Funding et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)
Glucocorticoid resistance in inflammatory diseases
Peter J. Barnes et al.
LANCET (2009)
Targeting innate immunity protein kinase signalling in inflammation
Matthias Gaestel et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology
S. W. Jones et al.
OSTEOARTHRITIS AND CARTILAGE (2009)
Ser276 Phosphorylation of NF-κB p65 by MSK1 Controls SCF Expression in Inflammation
Laurent Reber et al.
PLOS ONE (2009)
The versatile role of MSKs in transcriptional regulation
Linda Vermeulen et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages
Robert M. Rowlett et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity
Achim Schlapbach et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-κB inhibition
Ilse Me Beck et al.
EMBO JOURNAL (2008)
Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases
Rasmus Boye Kjellerup et al.
EXPERIMENTAL DERMATOLOGY (2008)
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
Maria Buxade et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
MK2 and MK3 - a pair of isoenzymes?
Natalia Ronkina et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
The RSK factors of activating the Ras/MAPK signaling cascade
Audrey Carriere et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
MSK activation and physiological roles
J. Simon C. Arthur
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanisms
Jie Dong et al.
GENES & DEVELOPMENT (2008)
Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin
Georg Stoecklin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation - relevance in a mouse model of Parkinson's disease
Tobias Thomas et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Chaperone hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay
Kristina S. Sinsimer et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
Chun Kim et al.
NATURE IMMUNOLOGY (2008)
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Olga Ananieva et al.
NATURE IMMUNOLOGY (2008)
The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Immunology of asthma and chronic obstructive pulmonary disease
Peter J. Barnes
NATURE REVIEWS IMMUNOLOGY (2008)
The selectivity of protein kinase inhibitors: a further update
Jenny Bain et al.
BIOCHEMICAL JOURNAL (2007)
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets
Reinhard Winzen et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
Kumaravelu Jagavelu et al.
CIRCULATION RESEARCH (2007)
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
Rossana Zaru et al.
NATURE IMMUNOLOGY (2007)
Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): Possible role for its anti-psoriatic effect
Borbala Gesser et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Jiang-Ping Wu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation
Magdalena M. Gorska et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-β-activated kinase-1 (TAK1)-mediated signaling
Kate A. Alford et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
Gopal P. Sapkota et al.
BIOCHEMICAL JOURNAL (2007)
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
N. Ronkina et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Expression of interleukin-17F in a mouse model of allergic asthma
Shintaro Suzuki et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2007)
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK
Jeffrey A. Smith et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
Tam Luong Nguyen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity - Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
Ainsley A. Culbert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis
Martin Hegen et al.
JOURNAL OF IMMUNOLOGY (2006)
Gene deletion of MK2 inhibits TNF-α and IL-6 and protects against cerulein-induced pancreatitis
Anne Barbara Tietz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Diabetic cardiomyopathy - The search for a unifying hypothesis
IG Poornima et al.
CIRCULATION RESEARCH (2006)
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
E Hitti et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Protein expression of TNF-α in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2
C Johansen et al.
JOURNAL OF IMMUNOLOGY (2006)
MAPKAP kinases - MKs - two's company, three's a crowd
M Gaestel
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line
Rama P. Cherla et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2006)
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding
XZ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages
K Andersson et al.
CYTOKINE (2006)
Dual pathways for nuclear factor κB activation by angiotensin II in vascular smooth muscle -: Phosphorylation of p65 by IκB kinase and ribosomal kinase
LP Zhang et al.
CIRCULATION RESEARCH (2005)
NF-κB RelA phosphorylation regulates RelA acetylation
LF Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The Mnks are novel components in the control of TNFα biosynthesis and phosphorylate and regulate hnRNP A1
M Buxadé et al.
IMMUNITY (2005)
(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives:: A novel class of potent MSK-1-inhibitors
MJ Bamford et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives:: Further optimisation as highly potent and selective MSK-1-inhibitors
MJ Bamford et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
A new cellular signaling mechanism for angiotensin II activation of NF-κB -: An IκB-independent, RSK-mediated phosphorylation of p65
LP Zhang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
MS Cohen et al.
SCIENCE (2005)
Synthesis of a potent and selective inhibitor of p90 Rsk
DJ Maloney et al.
ORGANIC LETTERS (2005)
Negative regulation of NF-κB signaling by PIAS1
B Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection
R Lang
IMMUNOBIOLOGY (2005)
MK2-induced tristetraprolin: 14-3-3 complexes prevent stress granule association and ARE-mRNA decay
G Stoecklin et al.
EMBO JOURNAL (2004)
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
CA Chrestensen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κB through a common MEK extracellular signal-regulated kinase/p90rsk signaling pathway in response to distinct forms of DNA damage
GR Panta et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Regulation at multiple levels of NF-κB-mediated transactivation by protein acetylation
V Quivy et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
VS Carl et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2004)
Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis
C Kubisch et al.
GASTROENTEROLOGY (2004)
p53 induces NF-κB activation by an IκB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
J Bohuslav et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils
PY Coxon et al.
CELLULAR SIGNALLING (2003)
Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
H Tran et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Heat shock protein 27 association with the IκB kinase complex regulates tumor necrosis factor α-induced NF-κB activation
KJ Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inflammation and angiotensin II
Y Suzuki et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2003)
Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway
ATJ Wierenga et al.
EXPERIMENTAL HEMATOLOGY (2003)
Transcriptional activation of the NF-κB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
L Vermeulen et al.
EMBO JOURNAL (2003)
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
Y Shi et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
S Rousseau et al.
EMBO JOURNAL (2002)
Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
XK Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals
AG Eliopoulos et al.
EMBO JOURNAL (2002)
Heat shock factor 1 represses transcription of IL-1β gene through physical interaction with the nuclear factor of interleukin 6
Y Xie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
N Asokananthan et al.
JOURNAL OF IMMUNOLOGY (2002)
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
A Neininger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of anti-apoptotic gene mcl-1
MT Lin et al.
CARCINOGENESIS (2001)
MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells
YG Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2
U Knauf et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases
Y Hefner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Exaggerated human monocyte IL-10 concomitant to minimal TNF-α induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus
AK De et al.
JOURNAL OF IMMUNOLOGY (2000)
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
M Lasa et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
New insights into the role of COX 2 in inflammation
DW Gilroy et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2000)
CEP-1347 inhibits caerulein-induced rat pancreatic JNK activation and ameliorates caerulein pancreatitis
ACC Wagner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
Share Paper
