Journal
GENES
Volume 2, Issue 1, Pages 210-218Publisher
MDPI
DOI: 10.3390/genes2010210
Keywords
SET; MYND; Smyd1; Smyd2; Smyd3; transcriptional regulation; chromatin modifications; epigenetics; tumorigenesis
Categories
Ask authors/readers for more resources
The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available