Journal
FRONTIERS IN PHYSIOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2014.00096
Keywords
HIV; inflammation; connexins; atherosclerosis; ATP
Categories
Funding
- New Jersey Blood Center
- Alfred P. Sloan Foundation Minority fellowship
- Mount Sinai NeuroAIDS Disparities Summer Institute [R25 MH080663]
- National Institute of Mental Health grant [MH096625]
- PHRI funding
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In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions. Our work and the work of others, indicate that the opening of Pannexin-1 hemichannels and activation of purinergic receptors by extracellular ATP is essential for HIV infection, cellular migration, inflammation, atherosclerosis, stroke, and apoptosis. Thus, this review discusses the importance of purinergic receptors, Panx-1 hemichannels and extracellular ATP in the pathogenesis of several human diseases and their potential use to design novel therapeutic approaches.
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