Journal
FRONTIERS IN PHYSIOLOGY
Volume 4, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2013.00380
Keywords
bicarbonate transport; proton transport; El(+)-K+-ATPase; K(ca)3.1; IK; TMEM16A; ANO1; pancreatic duct
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Funding
- Danish Council for Independent Research \Natural Sciences
- Lundbeck Foundation
- Novo Nordisk Foundation
- Carlsberg Foundation
- Lundbeck Foundation [R17-2007-1366] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0007353] Funding Source: researchfish
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Along the gastrointestinal tract a number of epithelia contribute with acid or basic secretions in order to aid digestive processes. The stomach and pancreas are the most extreme examples of acid (H+) and base (HCO3-) transporters, respectively. Nevertheless, they share the same challenges of transporting acid and bases across epithelia and effectively regulating their intracellular pH. In this review, we will make use of comparative physiology to enlighten the cellular mechanisms of pancreatic HCO3- and fluid secretion, which is still challenging physiologists. Some of the novel transporters to consider in pancreas are the proton pumps (H+-K+-ATPases), as well as the calcium-activated K+ and Cl channels, such as K(ca)3.1 and TMEM16A/ANO1. Local regulators, such as purinergic signaling, fine-tune, and coordinate pancreatic secretion. Lastly, we speculate whether dys-regulation of acid-base transport contributes to pancreatic diseases including cystic fibrosis, pancreatitis, and cancer.
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