Journal
FRONTIERS IN PHYSIOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2012.00281
Keywords
computational modeling; electroencephalogram (EEG); epilepsy; heterogeneity; spatio-temporal patterns
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Funding
- British research councils EPSRC
- BBSRC and the University of Manchester
- EPSRC [EP/E050441/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E050441/1] Funding Source: researchfish
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The occurrence of seizures is the common feature across the spectrum of epileptic disorders. We describe how the use of mechanistic neural population models leads to novel insight into the dynamic mechanisms underlying two important types of epileptic seizures. We specifically stress the need for a spatio-temporal description of the rhythms to deal with the complexity of the pathophenotype. Adapted to functional and structural patient data, the macroscopic models may allow a patient-specific description of seizures and prediction of treatment outcome.
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